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Propafenone

CAT: 1410-M14930-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M14930-02Size:1 mL x 10 mM in DMSO
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Description
An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
CAS Number
54063-53-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
341.44
Molecular Formula
C21H27NO3
Notes
Research use only, not for human use.
Receptor
MRP1| Potassium Channel| Sodium Channel

Chemical Information

Propafenone

Propafenone is an aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It is a secondary alcohol, a secondary amino compound and an aromatic ketone. It is a conjugate base of a propafenone(1+).

CAS Number54063-53-5
PubChem CID4932
IUPAC Name1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one
Molecular FormulaC21H27NO3
Molecular Weight341.4
XLogP3.3
Topological Polar Surface Area58.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count11
Heavy Atom Count25
Formal Charge0
Complexity368
SMILES
CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
InChI
InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3
InChIKey
JWHAUXFOSRPERK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Propafenone
CAS: 54063-53-5
CID: 4932
Formula: C21H27NO3
MW: 341.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight341.4
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count11
Exact Mass341.19909372
Monoisotopic Mass341.19909372
Topological Polar Surface Area58.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity368
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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M32255-013- (2-Hydroxy-4,6-dimethoxyphenyl) -1- (4-hydroxyphenyl) -1-propanone

Alternative Products

CatalogName
T0866-01Propafenone
020029Propafenone Hydrochloride
T12811-01(S) -Propafenone
HY-B0432A-01Propafenone (hydrochloride)
RM-P161619-01(R) -Propafenone

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