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APR-246

CAT: 1410-M14875-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:1410-M14875-05Size:50 mg
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Description
APR-246 (PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity.
CAS Number
5291-32-7
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
199.25
Molecular Formula
C10H17NO3
Notes
Research use only, not for human use.
Receptor
P53activator|TrxR1inhibitor

Chemical Information

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo(2.2.2)octan-3-one

Eprenetapopt has been used in trials studying the treatment of Prostatic Neoplasms, Hematologic Neoplasms, and Platinum Sensitive Recurrent High-grade Serous Ovarian Cancer With Mutated p53.

CAS Number5291-32-7
PubChem CID52918385
IUPAC Name2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
Molecular FormulaC10H17NO3
Molecular Weight199.25
XLogP-0.1
Topological Polar Surface Area49.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count14
Formal Charge0
Complexity236
SMILES
COCC1(C(=O)C2CCN1CC2)CO
InChI
InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3
InChIKey
BGBNULCRKBVAKL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo(2.2.2)octan-3-one
CAS: 5291-32-7
CID: 52918385
Formula: C10H17NO3
MW: 199.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight199.25
XLogP3-0.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass199.12084340
Monoisotopic Mass199.12084340
Topological Polar Surface Area49.8 Ų
Heavy Atom Count14
Formal Charge0
Complexity236
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS3604873-01APR-246
BA176962-01APR 246
A13636-100APR-246 100mg
S7724-1gEprenetapopt (APR-246)
A13636-500APR-246 500mg
A13636-25APR-246 25mg
A13636-5APR-246 5mg
A13636-50APR-246 50mg
A13636-10APR-246 10mg
A13636-10mM-DAPR-246 10mM * 1mL in DMSO

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