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G 573

CAT: 1410-M13632-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1410-M13632-02Size:5 mg
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Description
G 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM; blocks MEK phosphorylation by BRAF (V600E) .
CAS Number
22868-35-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
228.68
Molecular Formula
C13H9ClN2
Notes
Research use only, not for human use.
Receptor
MEK

Chemical Information

G-573

G-573 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]furo[3,2-c]pyridine-2-carboxylic acid with the amino group of (2S)-1-(aminooxy)propan-2-ol. It has a role as an antineoplastic agent and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a monocarboxylic acid amide, an aromatic amine, a secondary alcohol, an organoiodine compound, an organofluorine compound, a furopyridine and a secondary amino compound.

CAS Number22868-35-5
PubChem CID46926364
IUPAC Name7-fluoro-3-(2-fluoro-4-iodoanilino)-N-[(2S)-2-hydroxypropoxy]furo[3,2-c]pyridine-2-carboxamide
Molecular FormulaC17H14F2IN3O4
Molecular Weight489.21
XLogP3.6
Topological Polar Surface Area96.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count27
Formal Charge0
Complexity521
SMILES
C[C@@H](CONC(=O)C1=C(C2=CN=CC(=C2O1)F)NC3=C(C=C(C=C3)I)F)O
InChI
InChI=1S/C17H14F2IN3O4/c1-8(24)7-26-23-17(25)16-14(10-5-21-6-12(19)15(10)27-16)22-13-3-2-9(20)4-11(13)18/h2-6,8,22,24H,7H2,1H3,(H,23,25)/t8-/m0/s1
InChIKey
ZEZHPEIEEFTILY-QMMMGPOBSA-N
Chemical Structure
2D Structure
2D structure of G-573
CAS: 22868-35-5
CID: 46926364
Formula: C17H14F2IN3O4
MW: 489.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight489.21
XLogP33.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass488.99971
Monoisotopic Mass488.99971
Topological Polar Surface Area96.6 Ų
Heavy Atom Count27
Formal Charge0
Complexity521
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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