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Pomalidomide

CAT: 1410-M13004-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:1410-M13004-01Size:10 mg
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Description
A potent inhibitor of TNF-α production; inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs.
CAS Number
19171-19-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
273.2441
Molecular Formula
C13H11N3O4
Notes
Research use only, not for human use.
Receptor
TNF-α

Chemical Information

Pomalidomide

Pomalidomide is an aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies. It has a role as an antineoplastic agent, an angiogenesis inhibitor and an immunomodulator. It is a member of isoindoles, an aromatic amine, a dicarboximide and a member of piperidones. It is functionally related to a thalidomide.

CAS Number19171-19-8
PubChem CID134780
IUPAC Name4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Molecular FormulaC13H11N3O4
Molecular Weight273.24
XLogP0.2
Topological Polar Surface Area110
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count20
Formal Charge0
Complexity504
SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N
InChI
InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChIKey
UVSMNLNDYGZFPF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pomalidomide
CAS: 19171-19-8
CID: 134780
Formula: C13H11N3O4
MW: 273.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight273.24
XLogP30.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass273.07495584
Monoisotopic Mass273.07495584
Topological Polar Surface Area110 Ų
Heavy Atom Count20
Formal Charge0
Complexity504
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-10984-01Pomalidomide

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