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A-485

CAT: 1410-M12959-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:1410-M12959-04Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective and, cell and in vivo active p300/CBP catalytic inhibitor with IC50 of 9.8/2.6 nM.
CAS Number
1889279-16-6
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
536.484
Molecular Formula
C25H24F4N4O5
Notes
Research use only, not for human use.
Receptor
HAT

Chemical Information

A-485

A-485 is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8 nM and 2.6 nM for p300 and CBP histone acetyltransferase (HAT), respectively.

CAS Number1889279-16-6
PubChem CID118958122
IUPAC NameN-[(4-fluorophenyl)methyl]-2-[(3R)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide
Molecular FormulaC25H24F4N4O5
Molecular Weight536.5
XLogP3.3
Topological Polar Surface Area108
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count38
Formal Charge0
Complexity941
SMILES
C[C@@H](C(F)(F)F)N(CC1=CC=C(C=C1)F)C(=O)CN2C(=O)[C@]3(CCC4=C3C=CC(=C4)NC(=O)NC)OC2=O
InChI
InChI=1S/C25H24F4N4O5/c1-14(25(27,28)29)32(12-15-3-5-17(26)6-4-15)20(34)13-33-21(35)24(38-23(33)37)10-9-16-11-18(7-8-19(16)24)31-22(36)30-2/h3-8,11,14H,9-10,12-13H2,1-2H3,(H2,30,31,36)/t14-,24+/m0/s1
InChIKey
VRVJKILQRBSEAG-LFPIHBKWSA-N
Chemical Structure
2D Structure
2D structure of A-485
CAS: 1889279-16-6
CID: 118958122
Formula: C25H24F4N4O5
MW: 536.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight536.5
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass536.16828253
Monoisotopic Mass536.16828253
Topological Polar Surface Area108 Ų
Heavy Atom Count38
Formal Charge0
Complexity941
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA4653-5A-485
BA166476-01A 485

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