P62-mediated mitophagy inducer

CAT: 1410-M12772-01Size: 1 gDry Ice: NoHazardous: No
CAT#:1410-M12772-01Size:1 g
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Description
P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.
CAS Number
1809031-84-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
392.156
Molecular Formula
C14H9IN4O2
Notes
Research use only, not for human use.
Receptor
Mitophagy

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