P62-mediated mitophagy inducer

• Description :

  P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.

• Stability :

  ≥ 2 years

• Purity :

  >98% (HPLC)

• Weight :

  392.156

• Molecular Formula :

  C14H9IN4O2

• Notes :

  Research use only, not for human use.

• Receptor :

  Mitophagy

• CAS Number :

  1809031-84-2