PF-06651600

CAT: 1410-M12700-01Size: 1 gDry Ice: NoHazardous: No
CAT#:1410-M12700-01Size:1 g
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-06651600 is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2; inhibits Th1 and Th17 cell differentiation and function, reduces disease pathology in rat adjuvant-induced arthritis as well as in mouse experimental autoimmune encephalomyelitis models; selectively targets γc cytokine pathways while preserving JAK1-dependent anti-inflammatory signaling such as the IL-10 suppressive functions following LPS treatment in macrophages and the suppression of TNFα and IL-1β production in IL-27-primed macrophages.Rheumatoid ArthritisPhase 2 Clinical
CAS Number
1792180-81-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
285.351
Molecular Formula
C15H19N5O
Notes
Research use only, not for human use.
Receptor
JAK

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