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PT2385

CAT: 1410-M12551-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M12551-02Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PT2385 (PT-2385) is a potent, selective, and orally active antagonist of HIF2α, binds to HIF2α PAS-B domain (Kd=50 nM) and disrupts HIF2α/ARNT dimer formation.
CAS Number
1672665-49-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
383.3417
Molecular Formula
C17H12F3NO4S
Notes
Research use only, not for human use.
Receptor
HIF/HIF Prolyl-hydroxylase

Chemical Information

PT-2385

PT-2385 is a selective HIF-2a inhibitor with a Ki of less than 50 nM.

CAS Number1672665-49-4
PubChem CID91754484
IUPAC Name3-[[(1S)-2,2-difluoro-1-hydroxy-7-methylsulfonyl-1,3-dihydroinden-4-yl]oxy]-5-fluorobenzonitrile
Molecular FormulaC17H12F3NO4S
Molecular Weight383.3
XLogP2.4
Topological Polar Surface Area95.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity686
SMILES
CS(=O)(=O)C1=C2[C@@H](C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O
InChI
InChI=1S/C17H12F3NO4S/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11/h2-6,16,22H,7H2,1H3/t16-/m0/s1
InChIKey
ONBSHRSJOPSEGS-INIZCTEOSA-N
Chemical Structure
2D Structure
2D structure of PT-2385
CAS: 1672665-49-4
CID: 91754484
Formula: C17H12F3NO4S
MW: 383.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight383.3
XLogP32.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass383.04391352
Monoisotopic Mass383.04391352
Topological Polar Surface Area95.8 Ų
Heavy Atom Count26
Formal Charge0
Complexity686
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C13362-1mgPT2385

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