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LY2874455

CAT: 1410-M11034-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:1410-M11034-04Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY2874455 is a potent, selective pan-FGFR inhibitor.
CAS Number
1254473-64-7
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
444.3
Molecular Formula
C21H19Cl2N5O2
Notes
Research use only, not for human use.
Receptor
FGFR1|FGFR2|FGFR3|FGFR4|VEGFR2

Chemical Information

Ly-2874455

LY2874455 has been used in trials studying the treatment of Advanced Cancer.

CAS Number1254473-64-7
PubChem CID46944259
IUPAC Name2-[4-[(E)-2-[5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Molecular FormulaC21H19Cl2N5O2
Molecular Weight444.3
XLogP3.5
Topological Polar Surface Area88.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count30
Formal Charge0
Complexity576
SMILES
C[C@H](C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3/C=C/C4=CN(N=C4)CCO
InChI
InChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1
InChIKey
GKJCVYLDJWTWQU-CXLRFSCWSA-N
Chemical Structure
2D Structure
2D structure of Ly-2874455
CAS: 1254473-64-7
CID: 46944259
Formula: C21H19Cl2N5O2
MW: 444.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight444.3
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass443.0915803
Monoisotopic Mass443.0915803
Topological Polar Surface Area88.9 Ų
Heavy Atom Count30
Formal Charge0
Complexity576
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19164167-01LY2874455

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