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GLPG-0492

CAT: 1410-M10803-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:1410-M10803-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A novel, orally active, non-steroidal selective androgen receptor modulator (SARM) with in vitro potency of 13 nM.
CAS Number
1215085-92-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
389.328
Molecular Formula
C19H14F3N3O3
Notes
Research use only, not for human use.
Receptor
Androgen Receptor (AR)

Chemical Information

Glpg-0492

Glpg0492 is under investigation in clinical trial NCT01130818 (First-in-Human Single Ascending Dose of GLPG0492).

CAS Number1215085-92-9
PubChem CID59317190
IUPAC Name4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Molecular FormulaC19H14F3N3O3
Molecular Weight389.3
XLogP2.9
Topological Polar Surface Area84.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity683
SMILES
CN1C(=O)N(C(=O)[C@@]1(CO)C2=CC=CC=C2)C3=CC(=C(C=C3)C#N)C(F)(F)F
InChI
InChI=1S/C19H14F3N3O3/c1-24-17(28)25(14-8-7-12(10-23)15(9-14)19(20,21)22)16(27)18(24,11-26)13-5-3-2-4-6-13/h2-9,26H,11H2,1H3/t18-/m1/s1
InChIKey
VAJGULUVTFDTAS-GOSISDBHSA-N
Chemical Structure
2D Structure
2D structure of Glpg-0492
CAS: 1215085-92-9
CID: 59317190
Formula: C19H14F3N3O3
MW: 389.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight389.3
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass389.09872580
Monoisotopic Mass389.09872580
Topological Polar Surface Area84.6 Ų
Heavy Atom Count28
Formal Charge0
Complexity683
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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