AVL-292

• Description:

  AVL-292 (Spebrutinib, CC-292) is a highly selective, covalent Btk inhibitor with IC50 of <1 nM; also less potently inhibits Yes, c-Src, Brk, Lyn, and Fyn with IC50s of 723 nM, 1.729 uM, 2.43 uM, 4.4 uM, and 7.15 uM, rspectively.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  423.4402

• Molecular Formula:

  C22H22FN5O3

• Notes:

  Research use only, not for human use.

• Receptor:

  BRK|BTK|c-Src|Lyn|Yes

• CAS Number:

  1202757-89-8