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Carbaglu

CAT: 1410-M10646-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M10646-02Size:1 mL x 10 mM in DMSO
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Description
Carglumic acid is an orphan drug used for the treatment of hyperammonaemia in patients with N-acetylglutamate synthase deficiency. This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood-brain barrier and cause neurologic problems, cerebral edema, coma, and death.
CAS Number
1188-38-1
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
190.15
Molecular Formula
C6H10N2O5
Notes
Research use only, not for human use.
Receptor
Carbamoyl-phosphate synthase

Chemical Information

Carglumic Acid

Carglumic acid is a urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia. It has a role as an orphan drug and a carbamylphosphate synthetase I activator. It is a N-acyl-L-glutamic acid and a member of ureas. It is a conjugate acid of a N-carbamoyl-L-glutamate(2-).

CAS Number1188-38-1
PubChem CID121396
IUPAC Name(2S)-2-(carbamoylamino)pentanedioic acid
Molecular FormulaC6H10N2O5
Molecular Weight190.15
XLogP-2.4
Topological Polar Surface Area130
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count13
Formal Charge0
Complexity227
SMILES
C(CC(=O)O)[C@@H](C(=O)O)NC(=O)N
InChI
InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1
InChIKey
LCQLHJZYVOQKHU-VKHMYHEASA-N
Chemical Structure
2D Structure
2D structure of Carglumic Acid
CAS: 1188-38-1
CID: 121396
Formula: C6H10N2O5
MW: 190.15
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight190.15
XLogP3-2.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass190.05897142
Monoisotopic Mass190.05897142
Topological Polar Surface Area130 Ų
Heavy Atom Count13
Formal Charge0
Complexity227
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
MBS576244Carbaglu

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