Products for Research Use Only
RegisterLogin

MK-8617

CAT: 1410-M10644-01Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:1410-M10644-01Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
A potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively.
CAS Number
1187990-87-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
443.45
Molecular Formula
C24H21N5O4
Notes
Research use only, not for human use.
Receptor
PHD1|PHD2|PHD3|PHD1, PHD2, PHD3

Chemical Information

MK-8617
CAS Number1187990-87-9
PubChem CID44230662
IUPAC NameN-[bis(4-methoxyphenyl)methyl]-6-oxo-2-pyridazin-3-yl-1H-pyrimidine-5-carboxamide
Molecular FormulaC24H21N5O4
Molecular Weight443.5
XLogP2.4
Topological Polar Surface Area115
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count33
Formal Charge0
Complexity730
SMILES
COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)NC(=O)C3=CN=C(NC3=O)C4=NN=CC=C4
InChI
InChI=1S/C24H21N5O4/c1-32-17-9-5-15(6-10-17)21(16-7-11-18(33-2)12-8-16)27-23(30)19-14-25-22(28-24(19)31)20-4-3-13-26-29-20/h3-14,21H,1-2H3,(H,27,30)(H,25,28,31)
InChIKey
WXLPERVDMILVIF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of MK-8617
CAS: 1187990-87-9
CID: 44230662
Formula: C24H21N5O4
MW: 443.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight443.5
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass443.15935417
Monoisotopic Mass443.15935417
Topological Polar Surface Area115 Ų
Heavy Atom Count33
Formal Charge0
Complexity730
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
M14568-01MK-0752
M12381-01MK-6169
M11576-01MK-8825
M10761-01MK-1064
M10626-01MK-8353
M10202-01MK-4074
M10091-01MK-3577
M10025-01MK-8033
M16688-01MK-4101
M16496-01MK-8141

Alternative Products

CatalogName
BA7798-5MK-8617
BM170837-01MK 8617

Popular Products