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Losartan

CAT: 1410-M10523-01Size: 1 EachDry Ice: NoHazardous: No
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Description
A selective, competitive angiotensin II receptor type 1 (AT1) antagonist (IC50=20 nM) for treatment of high blood pressure (hypertension) .
CAS Number
114798-26-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
422.9106
Molecular Formula
C22H23ClN6O
Notes
Research use only, not for human use.
Receptor
AT1receptor

Chemical Information

Losartan

Losartan is a biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position. It has a role as an antihypertensive agent, an anti-arrhythmia drug, an endothelin receptor antagonist and an angiotensin receptor antagonist. It is a member of imidazoles and a biphenylyltetrazole. It is a conjugate acid of a losartan(1-).

CAS Number114798-26-4
PubChem CID3961
IUPAC Name[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Molecular FormulaC22H23ClN6O
Molecular Weight422.9
XLogP4.3
Topological Polar Surface Area92.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count30
Formal Charge0
Complexity520
SMILES
CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
InChI
InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
InChIKey
PSIFNNKUMBGKDQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Losartan
CAS: 114798-26-4
CID: 3961
Formula: C22H23ClN6O
MW: 422.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight422.9
XLogP34.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass422.1621871
Monoisotopic Mass422.1621871
Topological Polar Surface Area92.5 Ų
Heavy Atom Count30
Formal Charge0
Complexity520
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
015682Losartan α-Butyl-losartan Aldehyde Adduct (Losartan Impurity)
B1072-1000Losartan
GTR19192011-01NO-Losartan A

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