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BIX02189 (b)

CAT: 1410-M10368-07Size: 200 mgDry Ice: NoHazardous: No
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CAT#:1410-M10368-07Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays.
CAS Number
1094614-85-3
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
440.54
Molecular Formula
C27H28N4O2
Notes
Research use only, not for human use.
Receptor
ERK5| MEK1| MEK2| MEK5| TGFβR1

Chemical Information

(Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide

3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide is an indolecarboxamide.

CAS Number1094614-85-3
PubChem CID135659062
IUPAC Name3-[N-[3-[(dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-N,N-dimethyl-1H-indole-6-carboxamide
Molecular FormulaC27H28N4O2
Molecular Weight440.5
XLogP4.5
Topological Polar Surface Area71.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity688
SMILES
CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N(C)C)O
InChI
InChI=1S/C27H28N4O2/c1-30(2)17-18-9-8-12-21(15-18)28-25(19-10-6-5-7-11-19)24-22-14-13-20(27(33)31(3)4)16-23(22)29-26(24)32/h5-16,29,32H,17H2,1-4H3
InChIKey
ZGXOBLVQIVXKEB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of (Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide
CAS: 1094614-85-3
CID: 135659062
Formula: C27H28N4O2
MW: 440.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight440.5
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass440.22122615
Monoisotopic Mass440.22122615
Topological Polar Surface Area71.9 Ų
Heavy Atom Count33
Formal Charge0
Complexity688
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
2670-1BIX02189
MBS3601113-01BIX02189 (d)
A21729-200BIX02189 200mg
A21729-50BIX02189 50mg
A21729-5BIX02189 5mg
A21729-100BIX02189 100mg
A21729-25BIX02189 25mg
A21729-2BIX02189 2mg
MBS3600368-01BIX02189 (c)
A21729-10BIX02189 10mg

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