L-Arginine-15N4 (hydrochloride)

L-Arginine-15N4 (hydrochloride)

• CAS Number: 204633-95-4
• UNSPSC Description: L-Arginine-15N4 (hydrochloride) is the 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis[1].
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds; NO Synthase
• Type: Isotope-Labeled Compounds
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/l-arginine-15n4-hydrochloride.html
• Purity: 98.0
• Solubility: H2O : 250 mg/mL (ultrasonic)
• Smiles: [15NH]=C([15NH2])[15NH]CCC[C@H]([15NH2])C(O)=O.Cl
• Molecular Weight: 214.64
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.|[3]Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12.|[4]Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported