Fosbretabulin

Fosbretabulin

• CAS Number: 222030-63-9
• UNSPSC Description: Fosbretabulin (Combretastatin A4 phosphate) is a vascular disruptor with antitumor activity against atypical thyroid carcinoma (ATC) cell lines and xenografts. Fosbretabulin inhibits tumor growth by inhibiting microtubule polymerization, inducing apoptosis, and suppressing angiogenesis in tumors[1].
• Target Antigen: Apoptosis; Microtubule/Tubulin
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/fosbretabulin.html
• Smiles: O=P(O)(O)OC1=C(C=CC(/C=C\C2=CC(OC)=C(C(OC)=C2)OC)=C1)OC
• Molecular Weight: 396.33
• References & Citations: [1]Mooney, et al. "A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome." Thyroid 19.3 (2009): 233-240.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 3