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FB49

CAT: 0804-HY-156278-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-156278-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FB49 is a highly selective inhibitor of Bcl-2-associated athanogene 3 (BAG3), with the Ki of 45 μM. FB49 inhibits the cell growth in human tumoral cells, but has no toxicity in human peripheral mononuclear cells. FB49 block cell cycle in G1 phase and to induce apoptosis as well as autophagy in medulloblastoma HD-MB03 treated cells[1].
UNSPSC
12352005
Target
Apoptosis; Autophagy
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fb49.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(C(C)C(N1CCOCC1)=O)C/2=O)SC2=C/C3=CC=CC(O)=C3O
Molecular Formula
C17H18N2O6S
Molecular Weight
378.40
References & Citations
[1]Budassi F, et al. Design, synthesis and biological evaluation of novel 2,4-thiazolidinedione derivatives able to target the human BAG3 protein [published online ahead of print, 2023 Sep 22]. Eur J Med Chem. 2023;261:115824.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T79770-01FB49

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