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Glucosylsphingosine

CAT: 0804-HY-N7745-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7745-01Size:1 mg
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Description
Glucosylsphingosine (lyso-Gb1) is a deacylated form of glucosylceramide with neurotoxicity and is also a noncompetitively inhibitor of glucocerebrosidase with a Ki value of 30 μM. Glucosylsphingosine is promising for research of Krabbe and Gaucher disease[1][2][3][4][5][6].
CAS Number
52050-17-6
Product Name Alternative
Glucopsychosine; Lyso-Gb1; Lyso-GL1
UNSPSC
12352005
Target
Drug Metabolite; Glycosidase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/glucosylsphingosine.html
Purity
99.68
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic)
Smiles
O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCCCC
Molecular Formula
C24H47NO7
Molecular Weight
461.63
References & Citations
[1]Hurvitz N, et al. Glucosylsphingosine (lyso-Gb1) as a Biomarker for Monitoring Treated and Untreated Children with Gaucher Disease. Int J Mol Sci. 2019 Jun 21;20 (12) :3033.|[2]Dekker N, et al. Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response. Blood. 2011 Oct 20;118 (16) :e118-27. |[3]Schueler UH, et al. Toxicity of glucosylsphingosine (glucopsychosine) to cultured neuronal cells: a model system for assessing neuronal damage in Gaucher disease type 2 and 3. Neurobiol Dis. 2003 Dec;14 (3) :595-601.|[4]Stahl-Meyer K, et al. Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells. PLoS One. 2022 Nov 21;17 (11) :e0277058. |[5]Atsumi S, et al. Accumulation of tissue glucosylsphingosine in Gaucher-like mouse induced by the glucosylceramidase inhibitor cyclophellitol. Arch Biochem Biophys. 1993 Jul;304 (1) :302-4. |[6]Lukas J, et al. Glucosylsphingosine Causes Hematological and Visceral Changes in Mice-Evidence for a Pathophysiological Role in Gaucher Disease. Int J Mol Sci. 2017 Oct 20;18 (10) :2192.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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