Canine IL-12 p70 Recombinant Protein

• Background:

  IL-12 is a member of the IL-12 family, which includes IL-12, IL-23, IL-27, and IL-35. Like other IL-12 family members, IL-12 is a heterodimeric cytokine. IL-12 is encoded by two separate genes, IL-12A (p35) and IL-12B (p40) . The active heterodimer, and a homodimer of p40 are formed following protein synthesis. IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-gamma and TNF-alpha from T and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-gamma.

• Description:

  The Canine IL-12 p70 yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Canine IL-12 p70 applications are for cell culture, ELISA standard, and Western Blot Control. Canine IL-12 p70 Specifications: (Molecular Weight: 57.9 kDa) (Amino Acid Sequence: IWELEKDVYV VELDWHPDAP GEMVVLTCHT PEEDDITWTS AQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGKVLSRSLL LIHKKEDGIW STDILKEQKE SKNKIFLKCE AKNYSGRFTC WWLTAISTDL KFSVKSSRGF SDPQGVTCGA VTLSAERVRV DNRDYKKYTV ECQEGSACPS AEESLPIEVV VDAIHKLKYE NYTSSFFIRD IIKPDPPTNL QLKPLKNSRH VEVSWEYPDT WSTPHSYFSL TFCVQAQGKN NREKKDRLCV DKTSAKVVCH KDAKIRVQAR DRYYSSSWSD WASVSCS **LINKER** RSLPTASPSP GIFQCLNHSQ NLLRAVSNTL QKARQTLDYI PCTSEEIDHE DITKDKTSTV EACLPLELTM NESCLASREI SLITNGSCLA SGKASFMTVL CLSSIYEDLK MYQMEFKAMN AKLLMDPKRQ IFLDQNMLTA IDELLQALNF NSVTVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRM MSYLNSS) . For research use only.

• Applications:

  Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control

• Homology:

  Canis lupus familiaris (dog)

• Storage Temperature:

  -20°C