Multi-species (Bovine, Caprine, Ovine) IL-5 ELISpot

• Background:

  IL-3, IL-5, and GM-CSF are important in regulating eosinophil development. Of these three cytokines, IL-5 is the most specific to the eosinophil lineage and is responsible for selective terminal differentiation of eosinophils. The IL-5 receptor is composed of an alpha and a beta-common chain. The alpha subunit is specific for the IL-5 molecule, whereas the beta-common subunit also recognized by IL-3 and GM-CSF. IL-5 is produced by both hematopoietic and non-hematopoietic cells including T cells, granulocytes, and natural helper cells. It is associated with the cause of several allergic diseases including allergic rhinitis and asthma.

• Description:

  Multi-species (Bovine, Caprine, Ovine) IL-5 ELISpot ELISpot contains Capture Antibody, Standard Control, and Detection Antibody for development of up to two (2) ELISpot assays. Other required materials and reagents are not supplied. The antibodies have been determined to function in an ELISpot with the Standard Control provided. Components may also be purchased separately. For research use only.

• Applications:

  ELISpot

• Homology:

  Bison bison bison (American buffalo), Bos gaurus (gaur), Bos indicus (zebu), Bos taurus (cattle), Capra hircus (goat), Ovis aries (sheep)

• Storage Temperature:

  2°C to 8°C