Human EGF ELISpot

• Background :

  EGF (Epidermal Growth Factor) is best known for having the ability to stimulate cell growth and proliferation. There are many EGF responses and they are regulated by seven ligands: EGF, transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), and epigen (EPGN) and four ErbB (HER) family receptor tyrosine kinases: EGFR/ErbB1, ErbB2, ErbB3 and ErbB4. EGF family members are important for development and promoting mitogenesis and differentiation of mesenchymal and epithelial cells. EGF acts as a mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. EGF plays a significant role in epithelial development, angiogenesis, regulation of gastric acid secretion, fibroblast proliferation, and colony formation of epidermal cells in culture. EGF dysregulation is also associated with the growth and progression of many cancers.

• Description :

  Human EGF ELISpot contains Capture Antibody, Standard Control, and Detection Antibody for development of up to two (2) ELISpot assays. Other required materials and reagents are not supplied. The antibodies have been determined to function in an ELISpot with the Standard Control provided. Components may also be purchased separately. For research use only.

• Applications :

  ELISpot

• Homology :

  Gorilla gorilla gorilla (western lowland gorilla), Homo sapiens (human), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee)

• Storage Temperature :

  2°C to 8°C