Bovine Oncostatin M (OSM) Polyclonal Antibody

• Background:

  OSM (Oncostatin M) is a secreted cytokine involved in homeostasis and most chronic illnesses. OSM, a member of the IL-6 (gp130) family of proteins, inhibits the proliferation of a number of tumor cell lines and plays a significant role in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociception, inflammation and metabolism. Of all IL-6-type cytokines studied so far, OSM displays the broadest signaling profile. LIF and OSM proteins activate the JAK/STAT pathway, the MAPK protein kinases ERK1 and ERK2, the stress-activated protein kinases p38 and c-Jun N-terminal kinase (JNK), the phosphatidylinositol-3-kinase (PI3K) AKT pathway and protein kinase C delta (PRKCD) . In addition, OSM exhibits many other effects by regulating the production of other cytokines including IL-6, G-CSF and GM-CSF in endothelial cells. OSM may be a tumor promoter that will provide a potential target for antiangiogenic therapy.

• Description:

  The Bovine Oncostatin M (OSM) polyclonal antibody is unlabeled and has been qualified for use in ELISA and Western blot applications. It is the capture antibody in the Kingfisher Biotech Bovine Oncostatin M ELISA. The Bovine Oncostatin M antibody was produced in rabbits and is antigen-affinity purified. The reactivity by species is: (Bovine OSM - Strong) (Canine OSM - None) (Human OSM - None) (Mouse OSM - None) (Swine OSM - Weak) . For research use only.

• Host:

  Rabbit

• Label:

  Unconjugated

• Applications:

  ELISA, ELISpot, Flow Cytometry, Neutralization, Western Blot

• Purification:

  Antigen-affinity

• Homology:

  Bos taurus (cattle)

• Storage Temperature:

  2°C to 8°C

• Scientific Category:

  Antibody