PRP19 Rabbit mAb

• Background :

  Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234) .

• Description :

  This is a PRP19 Rabbit mAb Recombinant Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  NMP200; nuclear matrix protein 200; pre-mRNA-processing factor 19; PRP19; PRP19/PSO4; PRPF19; PSO4; senescence evasion factor; SNEV; UBOX4

• Swiss Prot :

  Q9UMS4

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthesized peptide derived from human PRP19

• Clonality :

  Monoclonal

• Conjugation :

  Unconjugated

• Type :

  Recombinant Antibody

• Applications :

  WB, IHC, ICC/IF, FC

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Dilution :

  WB 1:500-1:2000, IHC 1:50-1:200, ICC/IF 1:50-1:200, FC 1:50

• Buffer :

  Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source :

  Rabbit

• Isotype :

  IgG