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Chk1 Rabbit mAb

CAT: 0866-RDSA66835Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0866-RDSA66835Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Chk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, embryonic development, and tumor suppression. Activation of Chk1 involves phosphorylation at Ser317 and Ser345 and occurs in response to blocked DNA replication and certain forms of genotoxic stress. While phosphorylation at Ser345 serves to localize Chk1 to the nucleus following checkpoint activation, phosphorylation at Ser317 along with site-specific phosphorylation of PTEN allows for reentry into the cell cycle following stalled DNA replication.
Description
This is a Chk1 Rabbit mAb Recombinant Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
Checkpoint; S. pombe; homolog of;1; CHEK1; CHK1; CHK1 checkpoint homolog (S. pombe) ; Serine/threonine-protein kinase Chk1
Swiss Prot
O14757
Reactivity
Human
Immunogen
A synthesized peptide derived from human Chk1
Clonality
Monoclonal
Conjugation
Unconjugated
Type
Recombinant Antibody
Applications
WB, IHC, ICC/IF, FC
Purification Method
Affinity purification
Assay Type
Antibody
Dilution
WB 1:500-1:2000, IHC 1:50-1:200, ICC/IF 1:50-1:200, FC 1:50
Buffer
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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