PRAS40 Rabbit mAb

• Background:

  PRAS40 interacts with Raptor in mTOR complex 1 (mTORC1) in insulin-deprived cells and inhibits the activation of the mTORC1 pathway mediated by the cell cycle protein Rheb. Phosphorylation of PRAS40 by Akt at Thr246 relieves PRAS40 inhibition of mTORC1. mTORC1 in turn phosphorylates PRAS40 at Ser183.

• Description:

  This is a PRAS40 Rabbit mAb Recombinant Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  40 kDa proline rich AKT substrate; AKT1 S1; AKT1 substrate 1 (proline rich) ; AKT1S1; Lobe; PRAS40; Proline rich akt substrate

• Swiss Prot:

  Q96B36

• Reactivity:

  Human, Mouse

• Immunogen:

  A synthesized peptide derived from human PRAS40

• Clonality:

  Monoclonal

• Conjugation:

  Unconjugated

• Type:

  Recombinant Antibody

• Applications:

  WB, IHC, IP, FC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Dilution:

  WB 1:500-1:2000, IHC 1:50-1:200, IP 1:50, FC 1:50

• Buffer:

  Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  40kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG