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Sob-AM2

CAT: 0804-HY-164495-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164495-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sob-AM2 is a potent substrate (Km=1.3 μM) targeting fatty acid amide hydrolase (FAAH) expressed in the brain and has blood-brain barrier permeability. Sob-AM2 delivers high concentrations of Sobetirome to the central nervous system with minimal peripheral systemic dose, thereby stimulating central thyroid hormone receptor β (TRβ). In addition, Sob-AM2 can prevent myelin and axon degeneration in experimental autoimmune encephalomyelitis (EAE) mice[1].
CAS Number
2128258-47-7
UNSPSC
12352005
Target
FAAH; Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sob-am2.html
Purity
98.5
Solubility
DMSO : 20 mg/mL (ultrasonic;warming)
Smiles
O=C(COC1=CC(C)=C(CC2=CC=C(C(C(C)C)=C2)O)C(C)=C1)NC
Molecular Formula
C21H27NO3
Molecular Weight
341.44
References & Citations
[1]Meinig J M, et al. Targeting fatty-acid amide hydrolase with prodrugs for CNS-selective therapy[J]. ACS chemical neuroscience, 2017, 8 (11) : 2468-2476.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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