Sob-AM2

• Description :

  Sob-AM2 is a potent substrate (Km=1.3 μM) targeting fatty acid amide hydrolase (FAAH) expressed in the brain and has blood-brain barrier permeability. Sob-AM2 delivers high concentrations of Sobetirome (HY-14823) to the central nervous system with minimal peripheral systemic dose, thereby stimulating central thyroid hormone receptor β (TRβ) . In addition, Sob-AM2 can prevent myelin and axon degeneration in experimental autoimmune encephalomyelitis (EAE) mice[1].

• CAS Number :

  [2128258-47-7]

• UNSPSC :

  12352005

• Target :

  FAAH; Thyroid Hormone Receptor

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Endocrinology; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/sob-am2.html

• Purity :

  98.5

• Solubility :

  DMSO : 20 mg/mL (ultrasonic;warming)

• Smiles :

  O=C(COC1=CC(C)=C(CC2=CC=C(C(C(C)C)=C2)O)C(C)=C1)NC

• Molecular Formula :

  C21H27NO3

• Molecular Weight :

  341.44

• References & Citations :

  [1]Meinig J M, et al. Targeting fatty-acid amide hydrolase with prodrugs for CNS-selective therapy[J]. ACS chemical neuroscience, 2017, 8 (11) : 2468-2476.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported