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TH34

CAT: 0804-HY-111818-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-111818-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3[1].
CAS Number
2196203-96-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/th34.html
Purity
99.52
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=C(NO)C1=CC=C(C)C(NCC2=CC=CC=C2)=C1
Molecular Formula
C15H16N2O2
Molecular Weight
256.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92 (8) :2649-2664.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC10; HDAC6; HDAC8

Chemical Information

3-(benzylamino)-N-hydroxy-4-methylbenzamide
CAS Number2196203-96-8
PubChem CID134159676
IUPAC Name3-(benzylamino)-N-hydroxy-4-methylbenzamide
Molecular FormulaC15H16N2O2
Molecular Weight256.30
XLogP2.6
Topological Polar Surface Area61.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count19
Formal Charge0
Complexity290
SMILES
CC1=C(C=C(C=C1)C(=O)NO)NCC2=CC=CC=C2
InChI
InChI=1S/C15H16N2O2/c1-11-7-8-13(15(18)17-19)9-14(11)16-10-12-5-3-2-4-6-12/h2-9,16,19H,10H2,1H3,(H,17,18)
InChIKey
PZBARTUEWCQNSN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(benzylamino)-N-hydroxy-4-methylbenzamide
CAS: 2196203-96-8
CID: 134159676
Formula: C15H16N2O2
MW: 256.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight256.30
XLogP32.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass256.121177757
Monoisotopic Mass256.121177757
Topological Polar Surface Area61.4 Ų
Heavy Atom Count19
Formal Charge0
Complexity290
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19168533-01TH34
A19873-100TH34 100mg
A19873-5TH34 5mg
A19873-25TH34 25mg
A19873-10TH34 10mg
A19873-1TH34 1mg
A19873-50TH34 50mg
A19873-10mM-DTH34 10mM * 1mL in DMSO

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