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Promegestone

CAT: 0804-HY-119384-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119384-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research[1].
CAS Number
34184-77-5
Product Name Alternative
R-5020; Surgestone
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Progesterone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/promegestone.html
Purity
99.14
Solubility
DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@]12[C@](C)(CC[C@]1([C@@]3(CCC4=CC(CCC4=C3CC2)=O)[H])[H])C(CC)=O
Molecular Formula
C22H30O2
Molecular Weight
326.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Clémentine Garoche, et al. Human and Zebrafish Nuclear Progesterone Receptors Are Differently Activated by Manifold Progestins. Environ Sci Technol. 2020 Aug 4;54 (15) :9510-9518.|[2]Michael A Kirby, et al. Progesterone Receptor-Mediated Actions Regulate Remodeling of the Cervix in Preparation for Preterm Parturition. Reprod Sci. 2016 Nov;23 (11) :1473-1483.|[3]Todd P Knutson, et al. Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs. J Hematol Oncol. 2017 Apr 17;10 (1) :89.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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CatalogName
MBS5783665Promegestone

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