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Waldiomycin

CAT: 0804-HY-N13059Size: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-N13059Size:Inquire
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1342200-33-2
UNSPSC Description
Waldiomycin is an antibiotic that can be isolated from Streptomyces sp. MK844-mF10 that has inhibitory effects on low GC-content Gram-positive bacteria. Waldiomycin inhibits the activity of WalK kinase by targeting its ATP-binding domain, thereby blocking the WalK/WalR signal transduction system, which plays a role in cell growth and division[1][2].
Target Antigen
Antibiotic
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/waldiomycin.html
Smiles
O=C1C2=C(C(C3=C(O)C([C@@H]4O[C@@H]([C@H](CC4)OC(/C=C/C=C/C=C/[C@@H]5O[C@](C)(O[C@H]5C)C(O)=O)=O)C)=CC=C31)=O)C=CC(C[C@@](O)([C@@H]6O)C)=C2C6=O
Molecular Weight
702.70
References & Citations
[1]Igarashi, et al. Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp. MK844-mF10. The Journal of antibiotics 66.8 (2013): 459-464.|[2]Ishikawa, et al. Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial histidine kinases. The Journal of Antibiotics (2024): 1-11.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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CatalogName
GTR19236159-01Waldiomycin

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