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Icenticaftor

CAT: 0804-HY-109177-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109177-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC50s of 79 nM and 497 nM for F508del and G551D CFTR, respectively. Icenticaftor can be used for chronic obstructive pulmonary disease (COPD) and cystic fibrosis research[1].
CAS Number
1334546-77-8
Product Name Alternative
QBW251
UNSPSC
12352005
Hazard Statement
H315, H319
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/icenticaftor.html
Purity
99.66
Solubility
DMSO : 150 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NC(OC)=C(C(F)(F)F)C=C1N)NC[C@](C)(O)C(F)(F)F
Molecular Formula
C12H13F6N3O3
Molecular Weight
361.24
Precautions
H315, H319
References & Citations
[1]Darren Le Grand, et al. Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease. J Med Chem. 2021 Jun 10;64 (11) :7241-7260.|[2]Steven M Rowe, et al. Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial. Int J Chron Obstruct Pulmon Dis. 2020 Oct 5;15:2399-2409.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
BA6624-5Icenticaftor
C14572-25mgIcenticaftor (QBW251)

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