ADH-503

CAT: 0127-BUP13161-05Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0127-BUP13161-05Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2055362-74-6

Synonyms

GB1275

Purity

=95%

Smiles

C[N+](C)(C)CCO.[O-]C(=O)c1ccc(cc1)-c1ccc(\C=C2/SC(=S)N(Cc3ccccc3)C2=O)o1

Chemical Information

Adh-503

CD11b Agonist GB1275 is an orally bioavailable small molecule agonist of CD11b (integrin alpha-M; ITGAM; integrin alpha M chain), with potential immunomodulating activity. Upon administration, CD11b agonist GB1275 targets and binds to CD11b, thereby activating CD11b. This leads to CD11b-mediated signaling and promotes pro-inflammatory macrophage polarization while suppressing immunosuppressive macrophage polarization. This reduces influx of tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME), promotes anti-tumor immune responses, induces cytotoxic T-lymphocytes (CTLs) and suppresses tumor growth. CD11b, a member of the integrin family of cell adhesion receptors highly expressed on immune system cells, is a negative regulator of immune suppression and activates anti-tumor innate immunity.

CAS Number	2055362-74-6
PubChem CID	145711124
IUPAC Name	4-[5-[(Z)-(3-benzyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoate;2-hydroxyethyl(trimethyl)azanium
Molecular Formula	C27H28N2O5S2
Molecular Weight	524.7
Topological Polar Surface Area	151
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Heavy Atom Count	36
Formal Charge	0
Complexity	721

SMILES

C[N+](C)(C)CCO.C1=CC=C(C=C1)CN2C(=O)/C(=C/C3=CC=C(O3)C4=CC=C(C=C4)C(=O)[O-])/SC2=S

InChI

InChI=1S/C22H15NO4S2.C5H14NO/c24-20-19(29-22(28)23(20)13-14-4-2-1-3-5-14)12-17-10-11-18(27-17)15-6-8-16(9-7-15)21(25)26;1-6(2,3)4-5-7/h1-12H,13H2,(H,25,26);7H,4-5H2,1-3H3/q;+1/p-1/b19-12-;

InChIKey

GOWDQYRMBCOOJR-JHMJKTBASA-M

Chemical Structure

2D Structure

CAS: 2055362-74-6

CID: 145711124

Formula: C27H28N2O5S2

MW: 524.7

Interactive 3D Structure

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Computed Properties

Property	Value
Molecular Weight	524.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	524.14396435
Monoisotopic Mass	524.14396435
Topological Polar Surface Area	151 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	721
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	2
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
BA5884-100	ADH-503
C07232-25mg	ADH-503 (GB1275)
A24351-50	ADH-503 50mg
A24351-100	ADH-503 100mg
A24351-5	ADH-503 5mg
A24351-10	ADH-503 10mg
MBS131623-01	Amcasertib ?BBI503? BBI-503? BBI 503?
BA4664-25	MI-503
460613-01	NCT-503

ADH-503

Chemical Information

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