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ETC-206

CAT: 0127-BUP09742-03Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0127-BUP09742-03Size:25 mg
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CAS Number
1464151-33-4
Purity
=98%
Smiles
O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1

Chemical Information

Tinodasertib

Tinodasertib is a selective mitogen-activated protein kinase (MAPK)-interacting protein kinase (MNK) types 1/2 inhibitor with potential antineoplastic activity. Upon administration, tinodasertib may inhibit MNK1/2-dependent phosphorylation of eukaryotic initiation factor 4E (eIF4E) and interfere with its role in mRNA translation. eIF4E is an oncoprotein that must be phosphorylated before it can promote the proliferation and progression of tumor cells. MNKs are a family of serine/threonine kinases that have been implicated in oncogenic transformation and tumor progression.

CAS Number1464151-33-4
PubChem CID71766360
IUPAC Name4-[6-[4-(morpholine-4-carbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl]benzonitrile
Molecular FormulaC25H20N4O2
Molecular Weight408.5
XLogP3.9
Topological Polar Surface Area70.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count31
Formal Charge0
Complexity668
SMILES
C1COCCN1C(=O)C2=CC=C(C=C2)C3=CN4C(=NC=C4C5=CC=C(C=C5)C#N)C=C3
InChI
InChI=1S/C25H20N4O2/c26-15-18-1-3-20(4-2-18)23-16-27-24-10-9-22(17-29(23)24)19-5-7-21(8-6-19)25(30)28-11-13-31-14-12-28/h1-10,16-17H,11-14H2
InChIKey
FWRFPHJSGLYXTD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tinodasertib
CAS: 1464151-33-4
CID: 71766360
Formula: C25H20N4O2
MW: 408.5
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight408.5
XLogP33.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass408.15862589
Monoisotopic Mass408.15862589
Topological Polar Surface Area70.6 Ų
Heavy Atom Count31
Formal Charge0
Complexity668
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
PIC15133-01Etc-206
A19366-50Tinodasertib (ETC-206) 50mg
A19366-100Tinodasertib (ETC-206) 100mg
A19366-2Tinodasertib (ETC-206) 2mg
C12099-01ETC-206 (AUM 001)
A19366-500Tinodasertib (ETC-206) 500mg
A19366-25Tinodasertib (ETC-206) 25mg
A19366-10Tinodasertib (ETC-206) 10mg
A19366-5Tinodasertib (ETC-206) 5mg
A19366-10mM-DTinodasertib (ETC-206) 10mM * 1mL in DMSO

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