Products for Research Use Only
RegisterLogin

AMP-945

CAT: 0127-BUP07951-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0127-BUP07951-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1393653-34-3
Purity
=98%
Smiles
COc1cc(ccc1Nc1ncc(c(CCc2ccccc2CC(N)=O)n1)C(F)(F)F)C1CCN(C)CC1

Chemical Information

Narmafotinib

Narmafotinib is an orally bioavailable inhibitor of focal adhesion kinase 1 (FAK1; FAK; protein tyrosine kinase 2; PTK2), with potential antineoplastic activity. Upon oral administration, narmafotinib targets and inhibits FAK. This prevents FAK-mediated downstream signaling and inhibits migration, proliferation, invasion, and survival in FAK-overexpressing tumor cells. FAK, a non-receptor tyrosine kinase overexpressed in various tumor cell types, is involved in tumor cell survival, proliferation, migration and chemoresistance.

CAS Number1393653-34-3
PubChem CID60162119
IUPAC Name2-[2-[2-[2-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamide
Molecular FormulaC28H32F3N5O2
Molecular Weight527.6
XLogP4.6
Topological Polar Surface Area93.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Heavy Atom Count38
Formal Charge0
Complexity748
SMILES
CN1CCC(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)CCC4=CC=CC=C4CC(=O)N)C(F)(F)F)OC
InChI
InChI=1S/C28H32F3N5O2/c1-36-13-11-19(12-14-36)21-8-10-24(25(15-21)38-2)35-27-33-17-22(28(29,30)31)23(34-27)9-7-18-5-3-4-6-20(18)16-26(32)37/h3-6,8,10,15,17,19H,7,9,11-14,16H2,1-2H3,(H2,32,37)(H,33,34,35)
InChIKey
AWJVIOYPZZZYAX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Narmafotinib
CAS: 1393653-34-3
CID: 60162119
Formula: C28H32F3N5O2
MW: 527.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight527.6
XLogP34.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass527.25080977
Monoisotopic Mass527.25080977
Topological Polar Surface Area93.4 Ų
Heavy Atom Count38
Formal Charge0
Complexity748
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
BUP07690-01BLU-945
BUP00465-01AMP-Deoxynojirimycin
BUP17291-01Cyclic AMP
OR1030937-01Cyclic AMP Sodium
BUP01441-01AMP-PCP disodium
BITP1388-01Recombinant c-AMP dependant Protein Kinase A catalytic subunit alpha
BITP1389-01Recombinant c-AMP dependant Protein Kinase A regulatory subunit-1 alpha
BITP1392Recombinant c-AMP dependant Protein Kinase A regulatory subunit 2 alpha
BUP05483-01AMPC
OR1037181(S) -AMPA

Alternative Products

CatalogName
MBS3617290-01AMP-945
GL2252-25mgBLZ-945
MBS5801399BLU-945
BB178452-01BLZ 945

Popular Products