KA2507

CAT: 0127-BUP07736-05Size: 100 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0127-BUP07736-05Size:100 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

1636894-46-6

Purity

=98%

Smiles

ONC(=O)c1ccc(CN(c2cnccn2)c2cnccn2)cc1

Chemical Information

KA2507

HDAC6 Inhibitor KA2507 is an orally bioavailable inhibitor of histone deacetylase (HDAC) type 6 (HDAC6; HDAC-6), with potential antineoplastic activity. Upon administration, KA2507 targets, binds to and inhibits the activity of HDAC6. This results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. Specifically, inhibition of HDAC6 prevents STAT3 activity, which leads to a reduction in programmed death-1 (PD-1) expression. Eventually, this results in a selective transcription of tumor suppressor genes, tumor suppressor protein-mediated inhibition of tumor cell division and an induction of apoptosis in tumor cells that overexpress HDAC6. HDAC6, which is upregulated in many tumor cell types, deacetylates chromatin histone proteins.

CAS Number	1636894-46-6
PubChem CID	117703516
IUPAC Name	4-[[di(pyrazin-2-yl)amino]methyl]-N-hydroxybenzamide
Molecular Formula	C16H14N6O2
Molecular Weight	322.32
XLogP	0.3
Topological Polar Surface Area	104
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Heavy Atom Count	24
Formal Charge	0
Complexity	384

SMILES

C1=CC(=CC=C1CN(C2=NC=CN=C2)C3=NC=CN=C3)C(=O)NO

InChI

InChI=1S/C16H14N6O2/c23-16(21-24)13-3-1-12(2-4-13)11-22(14-9-17-5-7-19-14)15-10-18-6-8-20-15/h1-10,24H,11H2,(H,21,23)

InChIKey

LXHMTDHBMRZSHJ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1636894-46-6

CID: 117703516

Formula: C16H14N6O2

MW: 322.32

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	322.32
XLogP3	0.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	322.11782371
Monoisotopic Mass	322.11782371
Topological Polar Surface Area	104 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	384
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
BA4133-1	KA2507
T61322	KA2507 monohydrochloride
HY-138799A	KA2507 (monohydrochloride)
A24072-5	KA2507 5mg
A24072-50	KA2507 50mg
A24072-10	KA2507 10mg
A24072-100	KA2507 100mg

KA2507

Chemical Information

Alternative Products

Popular Products