L-372662

CAT: 0804-HY-15011-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-15011-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

L-372662 is a potent and orally active non-peptide oxytocin antagonist with a Ki value of 4.8. The Kd value of L-372662 for wild-type hOTR and [A318G]OTR is 5.8 nM and 73 nM. L-372662 shows selectivity to OTR:V1aR[1][2].

CAS Number

162045-26-3

UNSPSC

12352005

Target

Oxytocin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/l-372662.html

Purity

99.24

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC1)N(C2CCN(C(C3=C(OC)C=C(OC4CCN(CC5=C(C)[N+]([O-])=CC=C5)CC4)C=C3)=O)CC2)C6=C1C=CC=C6

Molecular Formula

C33H38N4O6

Molecular Weight

586.68

References & Citations

[1]Bell, I. M., Erb, J. M., Freidinger, R. M., Gallicchio, S. N., Guare, J. P., Guidotti, M. T., … Woyden, C. J. (1998) . Development of Orally Active Oxytocin Antagonists: Studies on 1- (1-{4-[1- (2-Methyl-1-oxidopyridin-3-ylmethyl) piperidin-4-yloxy]-2- methoxybenzoyl}piperidin-4-yl) -1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and Related Pyridines. Journal of Medicinal Chemistry, 41 (12), 2146–2163.|[2]Hawtin SR, et al. A Gly/Ala switch contributes to high affinity binding of benzoxazinone-based non-peptide oxytocin receptor antagonists. FEBS Lett. 2005;579 (2) :349-356.|[3]Williams PD, et al. Progress in the development of oxytocin antagonists for use in preterm labor. Adv Exp Med Biol. 1998;449:473-479.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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L-372662

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