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TPO

CAT: 0209-M10-087-L100Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-M10-087-L100Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant murine TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
Synonyms
TPO, Thrombopoietin, MGDF, Megakaryocyte colony-stimulating factor, c-MPL Ligand
NCBI Gene ID
21832
UniProt
P40226
Accession Number
NP_033405.1
Accession Number mRNA
NM_009379.3
Chromosomal Location
12 C; 12 15.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
SPVAPACDPRLLNKLLRDSHLLHSRLSQCPDVDPLSIPVLLPAVDFSLGEWKTQTEQSKAQDILGAVSLLLEGVMAARGQLEPSCLSSLLGQLSGQVRLLLGALQGLLGTQLPLQGRTTAHKDPNALFLSLQQLLRGKVRFLLLVEGPTLCVRRTLPTTAVPSSTSQLLTLNKF
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be < 1.0 ng/ml, corresponding to a specific activity of > 1 x 106 units/mg.
Length
174
Form
Lyophilized
Molecular Weight
18.7 kDa
Host or Source
E. coli

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