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TNF receptor type I, soluble

CAT: 0209-100-118-L1000Size: 2x 500 µgDry Ice: NoHazardous: No
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CAT#:0209-100-118-L1000Size:2x 500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NFkB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFR1) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. Recombinant human sTNFR1 is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFR1 protein.
Synonyms
TNFRSF1A; FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55
NCBI Gene ID
7132
UniProt
P19438
Accession Number
NP_001056.1
Accession Number mRNA
NM_001065.3
Chromosomal Location
12p13.2
Reactivity
Human
Cross Reactivity
Mouse, Rat, Human
Sequence
MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & FPLC analyses
Bioactivity
Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of recombinant human TNF-α, is 0.05 µg/ml.
Length
162
Form
Lyophilized
Molecular Weight
18.3 kDa
Host or Source
E. coli

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