TIGAR

CAT: 0209-100-429-L250Size: 250 µgDry Ice: NoHazardous: No
CAT#:0209-100-429-L250Size:250 µg
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Description
TIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. F-2-6-BP is a powerful activator of 6-phosphofructose-1 kinase, the rate limiting enzyme of glycolysis. By lowering the intracellular level of F-2-6-BP, TIGAR expression leads to increased glucose processing via the pentose phosphate pathway, the major cellular source for NADPH. Recombinant human TIGAR expressed in E. coli is a 29.9 kDa protein containing 269 amino-acid residues.
Synonyms
TP53-induced glyclysis and apoptosis regulator
NCBI Gene ID
57103
UniProt
Q9NQ88
Accession Number
NP_065108
Accession Number mRNA
NM_020375
Chromosomal Location
12p13.3
Reactivity
Human
Cross Reactivity
Human
Sequence
ARFALTVVRH GETRFNKEKI IQGQGVDEPL SETGFKQAAA AGIFLNNVKF THAFSSDLMR TKQTMHGILE RSKFCKDMTV KYDSRLRERK YGVVEGKALS ELRAMAKAAR EECPVFTPPG GETLDQVKMR GIDFFEFLCQ LILKEADQKE QFSQGSPSNC LETSLAEIFP LGKNHSSKVN SDSGIPGLAA SVLVVSHGAY MRSLFDYFLT DLKCSLPATL SRSELMSVTP NTGMSLFIIN FEEGREVKPT VQCICMNLQD HLNGLTETR
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Data not available.
Length
269
Form
Lyophilized
Molecular Weight
29.9 kDa
Host or Source
E. coli

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