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Resistin

CAT: 0209-M10-084-L1000Size: 1000 µgDry Ice: NoHazardous: No
CAT#:0209-M10-084-L1000Size:1000 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The three known members of this family; Resistin, RELM-α and RELM-β share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that Resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis. Recombinant murine Resistin is a 20.2 kDa disulfide-linked homodimeric protein composed of two identical 94 amino acid chains linked by a single disulfide bond.
Synonyms
Retn; ADSF; Rstn; Xcp4; Fizz3
NCBI Gene ID
57264
UniProt
Q99P87
Accession Number
NP_075360
Accession Number mRNA
NM_022984
Chromosomal Location
8 A1; 8 0.37 cM
Reactivity
Mouse
Cross Reactivity
Human, Rat, Mouse
Sequence
SSMPLCPIDE AIDKKIKQDF NSLFPNAIKN IGLNCWTVSS RGKLASCPEG TAVLSCSCGS ACGSWDIREE KVCHCQCARI DWTAARCCKL QVAS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Data not available.
Length
94
Form
Lyophilized
Molecular Weight
20.2 kDa
Host or Source
E. coli

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