Prolactin

• Description:

  Prolactin, also known as mammotrophin, luterotropic hormone, and lutetropin, is a neuroendocrine hormone secreted by the pituitary gland. Its primary function is to promote and maintain lactation during pregnancy and suckling. In addition, Prolactin plays an immune-regulatory role by stimulating the activities of ornithine decarboxylase and protein kinase C, which are important for the proliferation, differentiation, and function of lymphocytes. Recombinant human Prolactin is a 23 kDa globular protein containing 200 amino acid residues.

• Synonyms:

  Mammotropin, Luterotropic hormone, Lutetropin

• NCBI Gene ID:

  5617

• UniProt:

  P01236

• Accession Number:

  NP_000939.1

• Accession Number mRNA:

  NM_000948

• Chromosomal Location:

  6p22.2-p21.3

• Reactivity:

  Human

• Cross Reactivity:

  Rat, Human

• Sequence:

  MLPICPGGAA RCQVTLRDLF DRAVVLSHYI HNLSSEMFSE FDKRYTHGRG FITKAINSCH TSSLATPEDK EQAQQMNQKD FLSLIVSILR SWNEPLYHLV TEVRGMQEAP EAILSKAVEI EEQTKRLLEG MELIVSQVHP ETKENEIYPV WSGLPSLQMA DEESRLSAYY NLLHCLRRDS HKIDNYLKLL KCRIIHNNNC

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to induce the proliferation of rat Nb2-11 cells in the concentration range of 0.1-1.0 ng/ml.

• Length:

  200

• Form:

  Lyophilized

• Molecular Weight:

  23 kDa

• Host or Source:

  E. coli