Neuritin

• Description :

  Neuritin is a neurotrophic factor, which is expressed in response to induction of neuronal activity by NGF, BDNF, NT3, and other neural stimulators. It is expressed primarily in postmitotic-differentiating neurons of the developing nervous system and in neuronal structures related to synaptic plasticity in the adult nervous system. Neuritin acts as a molecular mediator of neurite outgrowth, neuronal survival, and synaptic maturation. Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.72 kDa polypeptide monomers, each containing 88 amino acid residues.

• Synonyms :

  CPG15, NRN1

• NCBI Gene ID :

  51299

• UniProt :

  Q9NPD7

• Accession Number :

  NP_057672.1

• Accession Number mRNA :

  NM_016588.2

• Chromosomal Location :

  6p25.1

• Reactivity :

  Human/Rat

• Cross Reactivity :

  Rat

• Sequence :

  AGKCDAVFKG FSDCLLKLGD SMANYPQGLD DKTNIKTVCT YWEDFHSCTV TALTDCQEGA KDMWDKLRKE SKNLNIQGSL FELCGSGN

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by a cell proliferation using rat C6 cells. The ED50 for this effect is 20.0-30.0 ng/ml.

• Length :

  88

• Form :

  Lyophilized

• Molecular Weight :

  9.72 kDa

• Host or Source :

  E. coli