Neuritin

• Description:

  Neuritin is a neurotrophic factor, which is expressed in response to induction of neuronal activity by NGF, BDNF, NT3, and other neural stimulators. It is expressed primarily in postmitotic-differentiating neurons of the developing nervous system and in neuronal structures related to synaptic plasticity in the adult nervous system. Neuritin acts as a molecular mediator of neurite outgrowth, neuronal survival, and synaptic maturation. Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.72 kDa polypeptide monomers, each containing 88 amino acid residues.

• Synonyms:

  CPG15, NRN1

• NCBI Gene ID:

  51299

• UniProt:

  Q9NPD7

• Accession Number:

  NP_057672.1

• Accession Number mRNA:

  NM_016588.2

• Chromosomal Location:

  6p25.1

• Reactivity:

  Human/Rat

• Cross Reactivity:

  Rat

• Sequence:

  AGKCDAVFKG FSDCLLKLGD SMANYPQGLD DKTNIKTVCT YWEDFHSCTV TALTDCQEGA KDMWDKLRKE SKNLNIQGSL FELCGSGN

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by a cell proliferation using rat C6 cells. The ED50 for this effect is 20.0-30.0 ng/ml.

• Length:

  88

• Form:

  Lyophilized

• Molecular Weight:

  9.72 kDa

• Host or Source:

  E. coli