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Nesfatin

CAT: 0209-100-142-L500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0209-100-142-L500Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2) . Originally identified as a hypothalamic neuropeptide, Nesfatin-1 is also expressed in other areas of the brain, and in pancreatic isletsβ-cells, gastric endocrine cells and adipocytes. Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner. Recombinant human Nesfatin-1 is a 9.7 kDa protein containing 82 amino acid residues.
Synonyms
Nesfatin, Nucleobindin 2 protein
NCBI Gene ID
4925
UniProt
P80303
Accession Number
NP_005004
Accession Number mRNA
NM_005013.2
Reactivity
Human
Cross Reactivity
Human
Sequence
VPIDIDKTKV QNIHPVESAK IEPPDTGLYY DEYLKQVIDV LETDKHFREK LQKADIEEIK SGRLSKELDL VSHHVRTKLD EL
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analysis
Bioactivity
Determined by an in vivo assay using healthy wild type male mice (C57BL/6J) . Mice were treated via intraperitoneal injection once at a dose of 4μg Nesfatin-1/gm of body weight. Significant effects on body weight and food consumption were observed relative to saline-treated controls.
Length
82
Form
Lyophilized
Buffer
10mM Sodium Phosphate, pH 6.6
Reconstitution
Water
Molecular Weight
9.7 kDa
Host or Source
E. coli

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