Myostatin

CAT: 0209-100-255-L500Size: 500 µgDry Ice: NoHazardous: No

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CAT#:0209-100-255-L500Size:500 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Myostatin is a TGF-beta family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of Myostatin activity facilitates muscle formation and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the Activin-binding protein Follistatin, and by the propeptide of Myostatin. Recombinant human Myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond.

Synonyms

MSTN; GDF8; MSLHP

NCBI Gene ID

2660

UniProt

O14793

Accession Number

NP_005250.1

Accession Number mRNA

NM_005259.2

Chromosomal Location

2q32.2

Reactivity

Human/Mouse/Rat

Cross Reactivity

Mouse, Rat, Human

Sequence

DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 98% by SDS-PAGE & HPLC analyses

Bioactivity

Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml.

Length

109

Form

Lyophilized

Molecular Weight

25 kDa

Host or Source

E. coli

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cyt-418-01	Myostatin
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YP-W13756-01	Human Myostatin (Myostatin) ELISA Kit
GTR18868354-01	Mouse Myostatin (Myostatin) ELISA Kit
JL52394-01	Rat Myostatin (myostatin) ELISA Kit
cyt-448-01	Myostatin Propetide
AK8256-0100	rHu Myostatin
30R-2662	Myostatin protein
M9875-03	Myostatin Propeptide
MBS850836-01	Myostatin Antibody

Myostatin

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