Myostatin

• Description :

  Myostatin is a TGF-beta family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of Myostatin activity facilitates muscle formation and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the Activin-binding protein Follistatin, and by the propeptide of Myostatin. Recombinant human Myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond.

• Synonyms :

  MSTN; GDF8; MSLHP

• NCBI Gene ID :

  2660

• UniProt :

  O14793

• Accession Number :

  NP_005250.1

• Accession Number mRNA :

  NM_005259.2

• Chromosomal Location :

  2q32.2

• Reactivity :

  Human/Mouse/Rat

• Cross Reactivity :

  Mouse, Rat, Human

• Sequence :

  DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml.

• Length :

  109

• Form :

  Lyophilized

• Molecular Weight :

  25 kDa

• Host or Source :

  E. coli