MDC (CCL22)

• Description:

  MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant murine MDC is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

• Synonyms:

  Ccl22; MDC; DCBCK; ABCD-1; Scya22

• NCBI Gene ID:

  20299

• UniProt:

  O88430

• Accession Number:

  NP_033163.1

• Accession Number mRNA:

  NM_009137.2

• Chromosomal Location:

  8 C5; 8

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Mouse

• Sequence:

  GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human activated lymphocytes using a concentration of 10.0-100.0 ng/ml.

• Length:

  68

• Form:

  Lyophilized

• Molecular Weight:

  7.8 kDa

• Host or Source:

  E. coli