Lin28-TAT

CAT: 0209-100-417-L250Size: 250 µgDry Ice: NoHazardous: No
CAT#:0209-100-417-L250Size:250 µg
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Description
Lin28 is a RNA-binding protein that belongs to a diverse family of structurally-related transcription factors. Lin28 is found abundantly in embryonic stem cells (ESCs), and to a lesser extent in placenta and testis. Lin28 has been shown to block let-7 microRNA processing and maturation, a necessary step in the differentiation of stem cells and certain cancer cell lines. Together with Sox2, Oct4, and Nanog, Lin28 can induce the reprogramming of primary human fibroblasts to a pluripotent state. Lin28 and other regulatory proteins can be introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing proteins into primary as well as transformed cells. Recombinant human Lin28-TAT is a 24.4 kDa protein containing 222 amino acid residues, including 13- residue C-terminal TAT peptide.
Synonyms
CSDD1, LIN28A, ZCCHC1, Zinc finger CCHC doamin-containing protein 1
NCBI Gene ID
79727
UniProt
Q9H9Z2
Accession Number
NP_078950.1
Accession Number mRNA
NM_024674.4
Chromosomal Location
1p36.11
Reactivity
Human
Cross Reactivity
Human
Label
TAT-Fusionprotein
Sequence
GPSVSNQQFA GGCAKAAEEA PEEAPEDAAR AADEPQLLHG AGICKWFNVR MGFGFLSMTA RAGVALDPPV DVFVHQSKLH MEGFRSLKEG EAVEFTFKKS AKGLESIRVT GPGGVFCIGS ERRPKGKSMQ KRRSKGDRCY NCGGLDHHAK ECKLPPQPKK CHFCQSISHM VASCPLKAQQ GPSAQGKPTY FREEEEEIHS PTLLPEAQNG GYGRKKRRQR RR
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 90% by SDS-PAGE & HPLC analyses
Bioactivity
Measured by its ability to induce fluorescence in Lin28 reporter cells (293 cells transfected with fluorescent protein genes under Lin28 control) . Optimum activity was achieved at 20 μg/ml after incubation for 72 hr.
Length
222
Form
Lyophilized
Molecular Weight
24.4 kDa
Host or Source
E. coli

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