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JE (MCP-1, CCL2)

CAT: 0209-M10-026-L100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-M10-026-L100Size:100 µg
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Description
The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross reacts across species. Recombinant murine JE is a 13.8 kDa protein containing 125 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
Synonyms
Ccl2; JE; HC11; MCAF; MCP1; MCP-1; Scya2; Sigje; SMC-CF; AI323594
NCBI Gene ID
20296
UniProt
P10148
Accession Number
NP_035463.1
Accession Number mRNA
NM_011333.3
Chromosomal Location
11 C-E1; 11 46.5 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse, Rabbit, Monkey, Bacteria
Sequence
QPDAVNAPLT CCYSFTSKMI PMSRLESYKR ITSSRCPKEA VVFVTKLKRE VCADPKKEWV QTYIKNLDRN QMRSEPTTLF KTASALRSSA PLNVKLTRKS EANASTTFST TTSSTSVGVT SVTVN
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract Balb/C mouse spleen MNCs using a concentration range of 1.0-20.0 ng/ml.
Length
125
Form
Lyophilized
Molecular Weight
13.8 kDa
Host or Source
E. coli

UniProtKB · P10148

C-C motif chemokine 2

CCL2_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P10148
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Ccl2
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q9QYD7
Protein keywords

Biological process

ChemotaxisInflammatory response

Molecular function

Cytokine

Technical term

Direct protein sequencingReference proteome

PTM

Disulfide bondGlycoproteinPyrrolidone carboxylic acid

Cellular component

Secreted

Domain

Signal

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