IL-15

• Description :

  IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowl disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant rat IL-15 is a 13.5 kDa protein consisting of 115 amino acid residues.

• Synonyms :

  Il15; 19q11

• NCBI Gene ID :

  25670

• UniProt :

  P97604

• Accession Number :

  NP_037261.1

• Accession Number mRNA :

  NM_013129

• Chromosomal Location :

  19q11

• Reactivity :

  Rat

• Cross Reactivity :

  Human, Mouse, Rat

• Sequence :

  MNWIDVRYDL EKIESLIQFI HIDTTLYTDS DFHPSCKVTA MNCFLLELQV ILHEYSNMTL NETVRNVLYL ANSTLSSNKN VIESGCKECE ELEERNFTEF LQSFIHIVQM FINTS

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 96% by SDS-PAGE & HPLC analyses

• Bioactivity :

  The ED50 as determined by the dose-dependant stimulation of the proliferation of murine CTLL-2 cells is < 10 ng/ml, corresponding to a specific activity of > 1 x 105 units/mg.

• Length :

  115

• Form :

  Lyophilized

• Molecular Weight :

  13.5 kDa

• Host or Source :

  E. coli